Wednesday, 5 December 2012

Genetic overlap between autism, schizophrenia and bipolar disorder

Aha...good sense from Carroll & Owen in 2009 [1]:

"It is clear that much future work is required and equally clear that this should not be constrained by current categorical diagnostic systems. Such studies should explore the relationship of genes and other biological variables to dimensional measures of key domains of psychopathology across current diagnostic categories. We have previously argued the need to undertake such endeavors across the functional psychoses of schizophrenia and bipolar disorder. However, recent data point to the need to consider a broader clinical spectrum that includes also autism and mental retardation/cognitive impairment

No reason to think that DSM-5 changes anything here.  

Note to self: must start posting here more to avoid need for embarrassing new year's resolutions.

[1]  Carroll LS,  Owen MJ (2009). Genetic overlap between autism, schizophrenia and bipolar disorder. Genome Medicine 1:102.

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